Representation of StMA gene occurrence (per 1000 CNV mapped genes) in autism CNV datasets (blue), schizophrenia (purple) and control datasets (green).

<p>The “dbVAR controls” represents a reference dataset created from the merger of all CNV loci derived from a series of control population datasets (shown in light green). </p

Genes and Psychosis (GAP) study sample characteristics.

<p>Genes and Psychosis (GAP) study sample characteristics.</p

Interaction between the schizophrenia polygenic risk score and reports of childhood adversity on presence of psychotic disorder.

<p>Interaction between the schizophrenia polygenic risk score and reports of childhood adversity on presence of psychotic disorder.</p

Prevalence of childhood adversities amongst first-presentation psychosis cases and unaffected controls.

<p>Prevalence of childhood adversities amongst first-presentation psychosis cases and unaffected controls.</p

Associations between the schizophrenia polygenic risk score and reports of childhood adversity.

<p>Associations between the schizophrenia polygenic risk score and reports of childhood adversity.</p

NAHR-mediated duplications and deletions of 16p13.11 identified in the BB-GRE referral cases.

<p>Abbreviations: Dupl, duplication; Del, deletion.</p>*<p>The sex of one of the cases carrying a duplication of intervals I, II and III was unknown, consequently, we were unable to include him/her in the male or female subgroup.</p

Frequency of phenotypic features in individuals with 16p13.11 duplications and deletions.

<p><b>°</b> This phenotype <b>i</b>ncludes the diagnosis of behavioural problems, ADHD and autism spectrum disorder.</p><p>ADHD was present only in duplication carriers (11.3%), but not in deletion carriers.</p>*<p>Not evaluated in very young cases.</p

NAHR-mediated duplications and deletions of 16p13.11.

<p>NAHR-mediated duplications (blue) and deletions (red) identified in the 16p13.11–p12.3 region (Chr16∶14.66–18.70 Mb, GRCh37/hg19) in cases and controls; case and control IDs refer to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061365#pone.0061365.s003" target="_blank">Table S1</a> and <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061365#pone.0061365.s004" target="_blank">Table S2</a>. Black solid bars indicate the three single copy sequence intervals in the region. Red and blue gene symbols represent ohnologs and other genes respectively. Segmental duplications and low copy repeats (LCRs) in the region are also shown.</p

Ohnologs in the 16p13.11–p12.3 region.

<p>Ohnologs in the 16p13.11–p12.3 region.</p

Frequency of NAHR-mediated 16p13.11 duplications and deletions in BB-GRE cases and controls.

<p>Abbreviations: CNV, copy number variant; OR, odds ratio; CI, confidence interval.</p